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目的观察依那普利联合胺碘酮治疗阵发性心房颤动的疗效。方法71例阵发性心房颤动病人随机分为治疗组和对照组。治疗组35例,每日口服依那普利5 mg,胺碘酮0.2 g;对照组36例,每日口服胺碘酮0.2 g,共治疗2年。结果治疗组2例、对照组7例发生持续性心房颤动(P<0.05)。治疗组2例、对照组8例发生缺血性脑卒中(P<0.05)。治疗组阵发性心房颤动发作次数较对照组显著减少。结论依那普利联合胺碘酮较单用胺碘酮可显著减少阵发性心房颤动的发作。
Objective To observe the efficacy of enalapril combined with amiodarone in the treatment of paroxysmal atrial fibrillation. Methods 71 patients with paroxysmal atrial fibrillation were randomly divided into treatment group and control group. The treatment group of 35 patients, daily oral enalapril 5 mg, amiodarone 0.2 g; control group of 36 patients, daily oral amiodarone 0.2 g, a total of 2 years. Results Two cases in the treatment group and seven cases in the control group had persistent atrial fibrillation (P <0.05). Two patients in the treatment group and eight patients in the control group had ischemic stroke (P <0.05). The incidence of paroxysmal atrial fibrillation in treatment group was significantly lower than that in control group. Conclusions Enalapril combined with amiodarone can significantly reduce the incidence of paroxysmal atrial fibrillation compared with amiodarone alone.