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目的通过回顾性分析糖尿病和非糖尿病人群中代表外周动脉硬化及僵硬度程度的肱踝脉搏波传导速度(ba PWV)、踝臂指数(ABI))与心脏收缩功能之间的相关性,探讨糖尿病对大血管及心脏收缩功能的影响。方法入组糖尿病患者48例,非糖尿病人群90例,均接受ba PWV、ABI及超声心动图检查,并留取血脂、糖化血红蛋白(Hb A1c)等相关临床资料。应用spearman相关分析各观察指标之间的相关性。结果基线资料比较显示,两组性别比例、血脂、尿酸水平差异均无统计学意义(P>0.05),Hb A1c、年龄差异有统计学意义(P<0.05);ABI、ba PWV差异有统计学意义(P<0.05)。心功能方面,左室射血分数(LVEF)、缩短分数(FS)差异无统计学意义(P>0.05)。组内分析显示,糖尿病组ABI与年龄、LVEF、Hb A1c之间存在相关性(相关系数r分别为0.67、0.42、0.47);ba PWV与年龄、BMI、Hb A1c及LVEF呈正相关(r分别为0.69、0.51、0.56、0.44)。非糖尿病组ABI同样与年龄、LVEF具有相关性(r分别为0.64、0.45);ba PWV与年龄、BMI、LVEF具有相关性(r分别为0.64、0.55、0.45)。结论无论在糖尿病还是非糖尿病人群中,ABI、ba PWV均与左室收缩功能的指标LVEF呈正相关性,即左室收缩功能受到外周动脉硬化及僵硬度的影响。
Objective To investigate the relationship between brachial-ankle pulse wave velocity (ba PWV), ankle-brachial index (ABI) and cardiac contractile function in diabetic and non-diabetic patients by retrospective analysis. Effects on Vasoconstriction and Heart Function. Methods 48 patients with diabetes mellitus and 90 non-diabetic patients underwent ba PWV, ABI and echocardiography. Serum lipids, HbA1c levels and other related clinical data were also collected. Spearman correlation analysis of the correlation between the various indicators. Results There was no significant difference in sex ratio, blood lipid and uric acid between the two groups (P> 0.05), but there was a significant difference in Hb A1c between the two groups (P <0.05). The differences of ABI and ba PWV were statistically significant Significance (P <0.05). Cardiac function, left ventricular ejection fraction (LVEF), fractional shortening (FS) was no significant difference (P> 0.05). In-group analysis showed that there was a correlation between ABI and age, LVEF and Hb A1c (r = 0.67, 0.42, 0.47, respectively); ba PWV was positively correlated with age, BMI, Hb A1c and LVEF 0.69, 0.51, 0.56, 0.44). ABI was also associated with age and LVEF in nondiabetic patients (r = 0.64 and 0.45, respectively); ba PWV was associated with age, BMI and LVEF (r = 0.64, 0.55 and 0.45, respectively). Conclusion Both ABI and ba PWV have a positive correlation with LVEF, which is the index of left ventricular systolic function in both diabetic and non-diabetic patients. That is to say, left ventricular systolic function is affected by peripheral arteriosclerosis and stiffness.