一九九四年度美国糖尿病会议报道,提取可作为糖尿病前期状态标记物的自身抗体将使我们能够预测胰岛素依赖性糖尿病患者(ID-DM),从而控制其临床发作。许多β细胞自身抗原与此有关,但最有希望成为标记物的是谷氨酸脱羧酶(GAD 65)抗体、胰岛素自身抗体及胰岛细胞自身抗体。但是,它们与糖尿病的关系很复杂。例如,胰岛细胞自身抗体滴度高预示着发病风险高,而弱阳性滴度则预示着发病风险低,但IDDM的进展并不能肯定。华盛顿大学的医学教授 The 1994 American Diabetes Conference reported that the extraction of autoantibodies that could serve as pre-diabetic status markers will enable us to predict insulin-dependent diabetes mellitus (ID-DM) and thus control its clinical course. Many beta-cell autoantigens are involved, but the most promising candidates are glutamate decarboxylase (GAD 65) antibodies, insulin autoantibodies and islet cell autoantibodies. However, their relationship to diabetes is complex. For example, high islet cell autoantibody titers indicate a high risk of disease, whereas weakly positive titers indicate a low risk of disease, but the progress of IDDM is not certain. Washington University professor of medicine