矽肺病是粉尘作业工人长期吸入大量石英粉尘后引起的以肺部纤维组织增生为主的一种严重的职业病。石英尘进入肺内立即被巨噬细胞(以下简称Mφ)所吞噬,但石英尘可破坏此Mφ而释出,然后被其它的Mφ吞噬,如此反复的结果导致大量Mφ坏死,进而发生肺部弥漫性纤维化。已有实验证明,在Mφ的吞噬活动中有补体C_3参与。关于补体C_3在矽肺发病过程中 Silicosis is a serious occupational disease caused by the prolonged inhalation of large amounts of quartz dust caused by dust-based workers’ lung fibrosis. Quartz dust into the lungs is immediately phagocytosed by macrophages (hereinafter referred to as Mφ), but the quartz dust can destroy the Mφ release, and then by other Mφ phagocytosis, so repeated results in a large number of Mφ necrosis, and then the occurrence of pulmonary diffuse Fibrosis. It has been experimentally demonstrated that complement C_3 is involved in phagocytosis of Mφ. About complement C_3 in the pathogenesis of silicosis