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微小病变肾病综合征(MCNS)和局灶节段性肾小球硬化(FSGS)是儿童肾病综合征的常见类型,具有许多相似的临床和病理特征、研究发现MCNS和 FSGS是免疫性疾病,MCNS患者的淋巴细胞产生的淋巴因子能引起肾小球基膜通透性增加,产生蛋白尿和肾病综合征,且MCNS患者的淋巴细胞功能异常,因此给鼠灌注MCNS和FSGS患者的末梢血单核细胞培养的上清液,以探讨淋巴细胞功能异常在MCNS和FSGS中的致病作用。材料和方法:本研究包括12例MCNS,8例FSGS,9例健康对照,用刀豆素刺激MCNS,FSGS
Minimal change nephrotic syndrome (MCNS) and focal segmental glomerulosclerosis (FSGS) are common forms of childhood nephrotic syndrome with many similar clinical and pathological features. Studies have found that MCNS and FSGS are immunological diseases and that MCNS Lymphocytes from patients with lymphocytes can cause increased glomerular basement membrane permeability, resulting in proteinuria and nephrotic syndrome, and MCNS patients with lymphocyte dysfunction, and thus to mice with MCNS and FSGS patients with peripheral blood mononuclear The cell culture supernatants were used to investigate the pathogenic role of lymphocyte dysfunction in MCNS and FSGS. Materials and Methods: This study included 12 MCNS patients, 8 FSGS patients and 9 healthy controls. Concanavalin was used to stimulate MCNS, FSGS