最近有关细胞毒素的资料激增,研究的重点已从细胞毒素抗肿瘤活性转变到对这些在炎症和防御中起作用的分子作更全面的分析。1987年1月20～22日在伦敦举行的一次专题讨论会上讨论了这些发展。 Carswell等首先将肿瘤坏死因子(TNF)描述为小鼠注射细菌产物后,其血清中显示的一种活性。原先采用卡介苗和革兰氏阴性菌细胞壁的主要成份——脂多糖(LPS或内毒素)作为诱导剂。由于观察到将这些血清注射到带瘤小鼠体内可导致肿瘤坏死,从而使人们对TNF的兴趣大为增加。嗣后,由于 Recent data on cytotoxics have proliferated and research has shifted from cytotoxic antitumor activity to a more comprehensive analysis of these molecules that play a role in inflammation and defense. These developments were discussed at a symposium held in London from January 20 to January 22, 1987. Carswell et al. First described tumor necrosis factor (TNF) as an activity shown in the serum of mice following bacterial injection. Originally used BCG and Gram-negative bacteria cell wall of the main components - lipopolysaccharide (LPS or endotoxin) as an inducer. Interest in TNF has been greatly increased as it has been observed that the injection of these sera into tumor-bearing mice results in tumor necrosis. Later, due