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各种对急性粒细胞白血病病人的回顾分析表明,在发生明显白血病之前,就可以看到血液学异常。1973年,Saarni和Linman复习了这些研究资料,并对34例发生急性非淋巴细胞白血病患者的血液学异常和临床表现作了比较,认为这些异常特点很一致,是可以作前瞻性分析的。“白血病前期”是Blook等在1953年提出来的。Linman建议用白血病前期综合征取代白血病前期,作为急性非淋巴细胞白血病发生前血液学异常的一个专用名称,包括多种曾以不同名称表示的疾病如Di Guglielmo氏综合征、慢性红白血病、慢性粒单细胞白
A review of various acute myeloid leukemia patients showed that hematologic abnormalities were seen before significant leukemia occurred. In 1973, Saarni and Linman reviewed these data and compared the hematologic abnormalities and clinical manifestations of 34 patients with acute non-lymphocytic leukemia. These abnormalities were characterized and prospectively analyzed. “Pre-leukemia” was proposed by Blook et al in 1953. Linman recommends replacing the pre-leukemia with pre-leukemia as a specialized name for pre-natal hematologic abnormalities in acute non-lymphocytic leukemia and includes a number of diseases that have previously been identified under different names such as Di Guglielm’s Syndrome, Chronic Leukemia, Chronic Leukemia Single cell white