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作者报告13例免疫缺陷病毒(HIV)感染的病人,接受抗病毒药物Zidovudine治疗后,6例出现充血性心力衰竭,心内膜心肌活检为活动性心肌炎。3例在Zidovudine治疗期间出现心功能低下;3例换用二脱氧肌甙(Dideoxyinosine ddI)及1例换用ddl和二脱氧胞嘧啶核甙(Dideoyxytidine ddC)后,出现心功能低下或加重。停止药物治疗后,心功能迅速恢复,重新治疗后复发。2例合并骨骼肌肌炎,为Zidovudine特征性毒性反应。抗病毒药物与心肌病
The authors report 13 patients with immunodeficiency virus (HIV) infection, receiving antiviral drugs Zidovudine treatment, 6 cases of congestive heart failure, endomyocardial biopsy for active myocarditis. Three patients had hypokalemia during the treatment of Zidovudine; 3 patients had dystonia (Dideoxyinosine ddI) and 1 patient switched to ddl and Dideoyxytidine ddC, with hypokalemia or aggravation. Stop drug treatment, rapid recovery of cardiac function, relapse after re-treatment. 2 cases with skeletal muscle myositis, Zidovudine characteristic toxicity. Antiviral drugs and cardiomyopathy