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本文应用放射免疫方法检测了40例慢性肺心病患者和35例正常人全血SOD-1含量。结果显示慢性肺心病患者急性发作期全血SOD-1含量显著高于正常对照组(P<0.001),缓解期显著低于正常对照组(P<0.001);重症慢性肺心病患者急性发作期全血SOD-1含量显著低于非重症组(P<0.01)。提示:慢性肺心病的临床病理过程有O_2参与,慢性肺心病急性发作期全血SOD-1含量高低对判断病情和估计预后有重要意义。
In this paper, radioimmunoassay was used to detect the content of SOD-1 in 40 patients with chronic cor pulmonale and 35 normal persons. The results showed that the content of SOD-1 in the whole blood of patients with chronic pulmonary heart disease was significantly higher than that of the normal control group (P <0.001) and the remission stage was significantly lower than that of the normal control group (P <0.001). The patients with severe chronic cor pulmonale Blood SOD-1 levels were significantly lower than non-severe group (P <0.01). It is suggested that O_2 is involved in the clinical pathological process of chronic pulmonary heart disease. The level of SOD-1 in whole blood in acute episodes of chronic pulmonary heart disease is of great significance in judging the condition and estimating the prognosis.