自青霉胺应用于临床治疗以来,已发现引起多种不良反应、少数严重性反应,常因剂量大和疗程长之故。主要反应有消化道功能紊乱、关节痛、胃纳差、肾病综合征、血液系统受损(粒细胞减少、血小板减少)和神经系统症状。这些可能与维生素B_6缺乏有关,可常规地应用维生素B_6加以避免。在皮肤方面的副作用中,不耐受或过敏现象最为常见,一般在用药后10～15天出现,有时仅几天,并能证明与青霉素有交叉反应性。表现为全身性或局限性红斑,或风团,尽管继续应用该药,这些皮疹可很快消退。Sternlieb等在33例中见到6例有这种皮疹,而Lievre则在22例中见到1例。皮疹有 Since penicillamine has been used in clinical treatment, it has been found that it causes a variety of adverse reactions, a small number of serious reactions, often due to large doses and long course of treatment. The main reactions are gastrointestinal disorders, joint pain, poor appetite, nephrotic syndrome, impaired blood system (neutropenia, thrombocytopenia) and neurological symptoms. These may be related to the lack of vitamin B_6, which can be routinely avoided with vitamin B_6. In the skin side effects, intolerance or allergy is the most common phenomenon, usually 10 to 15 days after treatment appears, and sometimes only a few days, and can prove cross-reactivity with penicillin. The performance of systemic or localized erythema, or wind group, despite the continued use of the drug, these rashes quickly subsided. Sternlieb and other 33 cases seen in 6 cases of this rash, while Lievre in 22 cases to see 1 case. Rash there