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在光电镜下观察了E14胎鼠脊髓及其被植入成鼠损伤脊髓后7、15、30、60、120和240天时的结构变化.结果表明:E14胎鼠脊髓主要由神经上皮细胞和神经母细胞构成.前者的超微结构特征是胞浆内富含游离核糖体,后者是在游离核糖体的基础上出Golgi体、内质网等细胞器.胶质细胞和轴突树突等均处于较原始的分化状态.值入后30天以内.胎鼠脊髓经历了由结构松散到逐渐致密为成熟神经组织的分化过程.其内神经元也经历了核糖体减少、细胞器增多、排列规范、核仁出现等发育分化过程.胶质细胞、轴突、树突和突触等渐具典型特征,同时可见大量新生神经纤维.此后,胎鼠脊髓更具成体脊髓的结构特证.直到术后240天,仍可观察到发育完善的胎鼠脊髓组织.作者认为.由于E14胎鼠脊髓的低分化度.将其移植后不但可以存活.也能继续发育分化,从而在成体脊髓损伤中至少起到了机械修补作用.
The morphological changes of E14 fetal rat spinal cord and its injured spinal cord were observed under light microscope at 7, 15, 30, 60, 120 and 240 days.The results showed that the spinal cord of E14 fetus was mainly composed of neural epithelium and nerve The former ultrastructural characteristics of the cytoplasm is rich in free ribosomes, which are based on the free ribosome Golgi body, endoplasmic reticulum and other organelles. Glial cells and axons dendrites Dengjun In the original state of differentiation.With the value of less than 30 days, the fetal rat spinal cord underwent a process from loose to dense gradually mature neural tissue differentiation process.The inner neurons also experienced ribosome reduction, organelles increased, the arrangement of norms, Nucleolus and other development and differentiation process glial cells, axons, dendrites and synapses gradually have the typical features, while visible a large number of nascent nerve fibers.Thereafter, fetal rat spinal cord more structural specificity of the spinal cord until after 240 days, still well-developed embryonic fetal spinal tissue can still be observed.The author believes that due to poor differentiation of E14 fetal rat spinal cord will not only survive after transplantation can also continue to develop differentiation, which in adult spinal cord injury at least Arrived Mechanical repair action.