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Objective:To explore the expression of adhesion factor E-cadherin and transcriptional factor Snail in Thyroid cancer,Thyroid adenoma and its clinical significance.Method:The SP immunohistochemisty method was used to investigate the expreesion of adhesion factor E-cadherin and transcriptional factor Snail in 20 Thyroid adenoma,46 Thyroid cancer.Result:The positive rate of E-cadherin in Thyroid adenoma was 75%,which was far higher than that in Thyroid cancer 26.1%(p<0.05).The positive rate of Snail in Thyroid adenoma was 30%,which was far lower than that in Thyroid cancer 65.2%(p<0.05).The expression of adhesion factor E-cadherin and transcriptional factor Snail was significantly related with the lymph node metastasis and the staging of TNM (p<0.05),and unrelated with the pathologic type, the age of patient and the sex of patient (p>0.05). There was negative correlation between the expression of E-cadherin and Snail in Thyroid cancer(rs=—0.710).Conclusions:1 The low expression of E-cadherin and high expression of snail may be one of the important biological symbol of vicious transformation in Thyroid cancer.2 The low expression of E-cadherin and high expression of snail may be can increase the ability of invasion and metastasis in tumour cell.3 Snail may be induce the occurring of EMT by influencing E-cadherin in Thyroid cancer, Snail and E-cadherin are significant negative correlation.