球形颗粒造粒机理研究

来源 :华东理工大学 | 被引量 : 0次 | 上传用户:myeclipse75
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The present work relates to a method and apparatus for making granules and particularly to methods and apparatuses available both for making spherical granules directly from wet mixtures of solids in powdered form and liquids,and for transforming wet granules in cylindrical shapes which are made by screw type extruders into spherical granules.In order to make spherical granules,the so-called "pellets;" it has been customary to use rotary drum type pelletizers,rotary pan type pelletizers and so forth.In these machines,a drum or a pan rotates slowly into which material in powdered form is fet and rolled in accordance with the rotation of the drum or the pan and it is finally agglomerated to spherical granules by the addition of liquids which act as binding agents.In these cases,granules can be made on a relatively large scale,but strictly speaking,the granules obtained are not spherical and different to a large extent in size and not uniform.Accordingly,in order to obtain uniform size granules,screening process is absolutely required after the granulation or the pelleting.Thus,it can be said that these methods and apparatuses or machines are not suitable for making spherical granules in uniform size particularly for making small spherical granules in uniform size on a commercial basis.In order to make spherical granules,a so-called pill making machines has been widely used in the pharmaceutical industry.The machine can make rather correct spherical granules in uniform size,but it has only small capacity for its motive power and dimensions required and it cannot make small shperical granules having a diameter under 2.0mm.due to ite mechanism.Since an extruded particle has at least two dimensions already defined,a narrow final particle size distribution is possible.Particles are fed onto the spinning friction plate,which throws them against the inside wall of the cylinder.Extruded particles are quickly broken into segments approximately one diameter long.Centrifugal and gravitational forces create a mechanically fluidized ring of particles.Collisions with the wall,friction plate and other particles result in the plastic deformation of each granule,quickly creating a spherical shape.The desired shape for a specific application is time and formulation dependent and is achieved,predictably and repeatedly,in a brief period called the "Spheronization time".One of the objects of the present work is to provide an apparatus for making samll spherical granules in uniform size rapidly in batch system.Another objects of the work is to provide the same apparatus operated in continuous system.
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