【摘 要】
：
该文探讨了一条工业上经济可行的合成抗菌药左氟沙星的关键中间体L-氨基丙醇[(S)-(+)-2-氨基-2-丙醇]的方法.我们以相应光学活性的L-氨基丙酸作为原料,先与无水乙醇(或甲醇)
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该文探讨了一条工业上经济可行的合成抗菌药左氟沙星的关键中间体L-氨基丙醇[(S)-(+)-2-氨基-2-丙醇]的方法.我们以相应光学活性的L-氨基丙酸作为原料,先与无水乙醇(或甲醇)反应生成酯,再经硼氢化锌还原后,用碱处理而得到产品,其中硼氢化锌由硼氢化钾和无水氯化锌反应制得.从而避免了拆分外消旋体的步骤,使实验方法得到简化,更适于工业化.该实验两步反应的最后总收率超过60﹪.
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