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Objective Piperacillin/tazobactam is beta-lactam antibiotic with a broad spectrum of activity,used for the treatment of mixed infections.The present study was to investigate piperacillin/tazobactam resistance to Gramnegative bacteria isolated in a teaching hospital in China during the past 8 years.Methods Disk diffusion test was used to study the antimicrobial resistance.The data were analyzed by WHONET 5 software according to Clinical and Laboratory Standards Institute (CLSI).Results The rates of extended spectrum beta-lactamases (ESBLs) in Klebsiella spp.and Escherichia coli were 51.2% ~65.1% and 43.6% ~60.1% during the past 8 years,respectively.The rates of resistance in Pseudomonas aeruginosa,Acinetobacter baumanii,ESBLs-positive and-negative Klebsiella spp.and E.coli to piperacillin/tazobactam were 15.5%~30.4%,13.0%~70.2%,16.9%~29.3%,4.9%~9.7%,13.0%~31.6% and 6.3%~10.3% during the past 8 years,respectively.Conclusion The change of the antimicrobial resistance should be investigated in order to guide direct rational drug usage in hospital and prevent bacterial strain of drug resistance from being transmitted.