Combinatorial approaches based on RAFT polymerization and coupling (or click) reaction were developed to synthesize well-defined silica-polymer hybrids.Chain-end-functionalized homopolymers were synthesized by RAFT polymerization of vinyl monomers mediated by functional trithiocarbonates in toluene or dioxane at 60 ℃, and di-, tri-, and tetrablock copolymers were further synthesized by successive chain extension polymerization.These polymers comprising trimethoxysilane or azide functionality in the chain end were then grafted to the surface of flash silica or silica nanoparticles by coupling or click reaction.IR and TGA results indicated the grafting ratios of polymeric chains on the surface of silica were relatively high.