高暴露地区儿童血清全氟化合物水平与血尿酸之间的关联性研究

来源 :第六届亚洲特大城市环境与公共健康论坛暨中国环境科学学会环境医学与健康分会2015年会 | 被引量 : 0次 | 上传用户:lxq19840808
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  目的 通过检测高暴露地区儿童血清中全氟化合物(PFASs)和尿酸水平,来探讨两者之间是否存在关联.方法 采用横断面研究法方随机抽取了台北市12-15岁的225健康儿童(男孩102人,女孩123人)并测量了血清中尿酸和PFASs的水平.采用线性回归和logistic回归来分析PFASs暴露与人体血尿酸水平之间的关系.结果 在所分析的全氟类化合物中,全氟辛酸(PFOA)的血清水平与儿童血尿酸水平之间存在关系,其中OR值为1.74 (95%CI: 1.21,2.50),调整OR值为2.13 (95%CI: 1.29,3.49);分性别分析,两者之间的相关关系仅仅体现在男性儿童,而女性儿童相关关系并不显著.结论 儿童血清PFASs水平与血尿酸水平升高之间存在关系,且男性儿童更加易感.
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