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目的:考察紫杉醇单药及联合化疗治疗各种晚期恶性肿瘤的毒副作用的临床表现及发生率。方法:采用回顾性分析法,对病房74例使用紫杉醇的病例进行分析。紫杉醇单独用药7例,合并其他抗肿瘤药67例,紫杉醇每例剂量135-200mg/m2,3小时静脉输注,紫杉醇化疗前后常规给予地塞米松、苯海拉明和雷尼替丁预防过敏反应,部分给予枢复宁预防呕吐。结果:共74例患者接受了化疗。血液学毒副反应主要为白细胞减少占36.48％、血红蛋白降低占18.91％,中性粒细胞减少14.86％。非血液学毒性反应主要为恶心、呕吐47.29％,食欲不振37.83％,肌肉及关节疼痛、手足麻木22.97％和脱发,一例严重腹泻,一例肾功能损害。
Objective: To investigate the clinical manifestations and incidence of side effects of paclitaxel alone and combined with chemotherapy in the treatment of various advanced malignancies. Methods: A retrospective analysis was performed to analyze 74 cases of paclitaxel used in the ward. Paclitaxel alone in 7 cases, combined with other anti-tumor drugs in 67 cases, paclitaxel in each dose of 135-200mg / m2, intravenous infusion of 3 hours, before and after paclitaxel chemotherapy routine dexamethasone, diphenhydramine and ranitidine to prevent allergic reactions , Part of the pill given to prevent vomiting. Results: A total of 74 patients received chemotherapy. Hematology toxic side effects mainly leukopenia accounted for 36.48%, hemoglobin decreased 18.91%, neutropenia 14.86%. The main non-hematological toxicity was nausea, vomiting 47.29%, loss of appetite 37.83%, muscle and joint pain, numb 22.97% of hands and feet and hair loss, a case of severe diarrhea, a case of renal dysfunction.