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The aims of this study were to detect the taurine levels in fetal rat brains with intrauterine growth restriction (IUGR),and to determine the influence of antenatal taurine supplementation on taurine levels in fetal rat brain with IUGR.Fifteen pregnant rats were randomly divided into three equal (n = 5) groups: normal control,IUGR,and IUGR + antenatal taurine supplement groups (taurine groups).The IUGR model was induced by a low protein diet throughout the gestation.Taurine was added to the diet of the taurine group at a dose of 300 mg/kg per day from 12 days after conception until natural delivery.Two fetal rats were randomly selected from each group and the taurine level in the fetal rat brain was detected using high performance liquid chromatography-mass spectrometry.The taurine levels in the fetal brains were 2.399 ± 0.134 in the normal control,1.881 ± 0.166 in the IUGR,and 2.170 ± 0.191 μg/mg in the taurine groups (F = 24.828,P< 0.01).Taurine levels in the IUGR fetal rat brain were lower than in the normal controls,and antenatal taurine supplementation significantly increased the taurine levels in the fetal rat brains with IUGR.