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To investigate the role of Tim-4 in macrophage modulation.In this study, we evaluated the effect of Tim-4 on NO production in LPS induced RAW264.7 macrophages.The results showed that NO production and iNOS expression in T4-RAW cells (RAW264.7 cells stably transfected with Tim-4 expressing plasmid) were significantly lower than those in control cells induced by LPS, while Tim-4 blockade promoted LPS induced NO production and iNOS expression in Raw264.7 macrophages.