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A folk prescription consisting of Alnus hirsuta, Rosa davurica, Acanthopanax senticosus and Panax schinseng has been used to treat diabetes mellitus in Gangwon-Do, Korea.The aim of the present investigation was to evaluate the antidiabetic effect of herb formula extract (HFE) composed of Alnus hirsuta, Rosa davurica, Acanthopanax senticosus and Panax schinseng in streptozotocin (STZ)-induced diabetic rats.