Background ASD is characterized by impairments in social interaction and communication and the presence of restrictive and stereotyped patterns of behaviours, interests, and activities.Historically, autism was considered a rare condition, however, a number of recent studies indicate that prevalence rates may be as high as 1% for the broader autism spectrum.Thus, autism can no longer be considered a rare neurodevelopmental condition.In 15-30% of children with autism there is a period of stasis of development and even loss of skills, most commonly speech.Children with autism rehabilitation is a systematic social problem.This has provoked significant media and public concern.The researchers used computer to search the articles related to the QOL of autism in the digital library database ,CHKD periodical and Pubmed.It proved that more research on the quality of life for children with autism and their parents abroad [2-3].However, the original study was flawed by ascertainment etiology , pathogenesisand early autistic symptoms.Domestic rare research reports on the quality of survival.Moreover, compared with other conditions there has been a lack of focus on quality of life (QoL).With the conversion of the biomedical model to the bio-psycho-social medical model, measuring for children and young people with Autism Spectrum Disorder (ASD), Thinking about how to improve the quality of life [8] is more and more attention.The most widely used diagnostic criteria for AD are those described in the revised text edition of the Diagnostic and Statistical Manual of Mental Disorders(DSM-Ⅳ-TR) of the American Psychiatric Association (APA, 2000).This study examined Pediatric Quality of Life (PQOL) of children with autism, from a multidimensional perspective.The proposed model was based on the Cross-sectional survey, with Physiological function, emotional function, social function, and school performance as components.This study aimed to evaluate the validity of existing QoL questionnaires for use with children with ASD aged 8-12 years.Method Two hundred children (male 118, female g2 cases; 2-4 years old, g0 cases ,S-7-year-old, 87 cases ,8-12 years old, 33 cases) with autism and 120 normal children, as control, articipated in the study.Separate path analyses were performed to evaluate models of QOL and Intelligent evaluation, the PedsQL (Pediatric Quality of Ufe Inventory) as robust measures used with children with neurodevelopmental disorders.Results In the study, The examed group had lower scores on the PedsQL4.0 universality Core scale, in comparison with the normal group.Behaviour problems had a negative indirect effect on Community adaptation,mental health and school performance.And a lower intelligence-related quality of life for children with autistic disorder and clinically significant autistic symptoms in comparison with children and fewer symptoms.Conclusions Results suggest greater impairment in adaptive functioning and emotional disorders.For high-functioning autism children, potential positive development played significant roles in rehabilitation, to achieve and maintain the best level of intervention.the severity of the disorder and social support Coping strategies were related with Life self-care ability and adaptation,coping with Intelligent obstacle seriously.Physicians are encouraged to evaluate for early treatment in the overall care plan.