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NPC1 gene is an important gene closely related to the Niemann-Pick type C (NPC).Previous studies have shown that NPC 1 protein plays an important role in subcellular lipid transport, homeostasis, platelet function and formation, which are basic metabolic activities in the process of development.In this study, to explore the association between NPC 1 variation and growth traits in Qinchuan cattle, we detected four novel coding single nucleotide polymorphisms (cSNPs) in the bovine NPC1 gene, including one missense mutation and three synonymous mutations.Population genetic analyses of 518 individuals and association correlations between cSNPs and bovine growth traits were conducted in this research.A missense mutation was found to be closely related to the heart girth, hip width and body weight (P<0.01 or P<0.05) (3.5-year-old).Two synonymous mutations showed significant effects on hip width (P<0.05) (3.5-year-old).One synonymous mutation showed significant effect on body weight (P<0.05) (2.0-year-old).Combined haplotypes H2H6 and H6H6 showed significant effects on growth traits such as heart girth, hip width, and body weight (3.5-year-old)(P<0.01 or P<0.05).This study provides evidence that NPC1 gene might be involved in the regulation of bovine growth and body development, and may be considered as a candidate gene for marker assisted selection in beef cattle breeding industry.