Cellular biophysical properties(i.e.,membrane capacitance and deformability)are promising biophysical markers for cell status evaluation and cell type classification.In this talk,I will present our recent work on developing microfluidic platforms enabling the characterization of intrinsic cellular biophysical properties including specific membrane capacitance and instantaneous Youngs modulus in a continuous manner.From the perspective of technology development,I will present five-generation microfluidic platforms for cellular biophysical property quantification and highlight the proposed equivalent electrical and mechanical models for raw electrical/mechanical data translation.As to applications,I will report the classification of paired high-and low-metastatic carcinoma strains as well as tumor cells and their counterparts with single oncogenes under regulation based on cellular biophysical properties.The microfluidic platforms developed in this study show promise in tumor cell type classification,which may function as effective tools in further clinical applications.