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Objective:To explore the role of KLF2 and RelA in neutrophil apoptosis of neutrophilic asthma.Methods:Forty adult male guinea pigs were ramdomly divided into three groups:control group (group A),neutrophilic asthma group (group B),neutrophilic asthma treatment group (group C).Detect apoptosis rate of neutrophils,the expression of KLF2/RelA mRNA and protein in neutrophils of BALF and blood.