The aim of the present study was to development a pharmacokinetic/pharmacodynamic (PK/PD) model for the characterization ofperindopril effect in spontaneously hypertensive rats (SHRs) while taking into account natural disease progression in baseline and the influence of handling.A two-compartment model with first-order absorption was applied to describe the pharmacokinetic characteristics ofperindoprilat, an active metabolite of perindopril.The long-term drug concentration data was obtained from simulation.