The NMDA glutamate receptor (GluNR) contributes to the development and plasticity of the mammalian brain but can have patho-physiological effects.Midbrain dopaminergic neurones (DA neurones) form a critical part of the basal ganglia, involved in motivation, action and learning, but are vulnerable to cell death in Parkinsons disease (PD).We have studied the types and properties of GluNRs in midbrain DA neurones.We have previously shown that GluNRs in substantia nigra DA neurones have properties consistent with GluN2B and GluN2D-containing receptors.I will present evidence that D-serine activated GluN3-containing receptors are also present.