Bioaccessibility refers to the maximum bioavailability of pollutant ingested with food,and its measurements can lead to a more accurate risk assessment as compared to the measurements of total concentrations of pollutant in food.This study examined the factors affecting the bioaccessibility of methylmercury(MeHg)in nine species of marine fish with an aim to identify ways of reducing MeHg bioaccessibility.MeHg bioaccessibility without any treatment in the nine species of marine fish ranged from 16.0 to 67.7%.Steaming,grilling,and frying reduced MeHg bioaccessibility by 29.477.4%for rabbitfish and 74.695.8%for grouper.Co-consumption of phytochemical-rich foods such as green tea decreased the bioaccessibility of MeHg by 72.2%for rabbitfish and 74.0%for grouper,whereas meso-2,3-dimercaptosuccinic acid increased it by 39.2108%for rabbitfish and 45.375.7%for grouper.The bioaccessibilities of both MeHg and inorganic mercury were independent of the total Hg concentration and the exposure route(dietary vs dissolved).In eight of the nine species studied,bioaccessibility was negatively correlated with the extent to which MeHg was partitioned into the metal-rich granule fraction and the trophically available fraction.It was positively correlated with partitioning into the cellular debris fraction.This study demonstrated the important control of subcellular distribution in MeHg bioaccessibility.