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Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins are evolutionarily conserved molecular machines that couple their folding/assembly to drive diverse intracellular membrane fusion.SNARE-mediated membrane fusion underlies numerous basic processes in humans, including neurotransmission, hormone secretion, and antibody production.Malfunction of fusion has been associated with many important diseases such as neurological disorders and diabetes.