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Codelivery of different therapeutics has a potential to efficaciously treat human diseases via their synergetic effects.Activable therapeutic tools at the nanoscale are suitable platforms for codelivery of different therapeutics,including nucleic acids and chemotherapeutics.We have recently developed a multifunctional nanoscaled delivery system simultaneously applied with tumor-targeted,pH-triggered and eodelivery strategies.In this study,DOX-HZN-PEI-PEG-TAT was first synthesized and complexed with pDNA to form DOX loaded-TAT modified polyion complex micelles (PIC).