@@Poly(dimethylsiloxane) (PDMS), as an attractive material, has become a popular material for building microfluidic devices mainly due to its easy fabrication, good optical transparency, easy sealing with other materials,non-toxicity, low cost, increasing versatility, and relatively low curing temperature [1–3]. However, there are also some disadvantages to the use of PDMS [4], which include easy generation of air bubble in channels, extreme hydrophobicity of PDMS that makes the devices difficult to wet with aqueous solution and absorb analyte, and poorly defined electroosmotic flow (EOF) [3]. To improve the stability of EOF, make the surface more hydrophilic, eliminate adsorption and improve the separation efficiency, much research is aimed at exploiting novel materials for fabricating PDMS microchips.