【摘 要】
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The aim of the study was to investigate the competency of selenium(Se)in counteracting the adverse effects of aflatoxin B1(AFB1)on apoptosis,cell cycle and
【机 构】
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Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province,College of Veterinar
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The aim of the study was to investigate the competency of selenium(Se)in counteracting the adverse effects of aflatoxin B1(AFB1)on apoptosis,cell cycle and proliferation of nephritic cells.240,one-day-old healthy male avian broilers were randomly divided into four groups and fed with basal diet(control group),0.3 mg/kg AFB1 diet(AFB1 group),0.4 mg/kg Se diet(+Se group)and 0.3 mg/kg AFB1+0.4 mg/kg Se diet(AFB1+Se group),respectively.Compare to the control group,the number of apoptotic renal cells,expressions of Bax and Caspase-3 mRNA were significantly increased,while the expression of Bcl-2 was significantly decreased in AFB1 and+Se groups(P<0.01).A significant decreased proliferating cell nuclear antigen(PCNA)expression and arrested G0/G1 phases of the cell cycle were also seen in the AFB1 and+Se groups when compared with those of the control group.Moreover,these parameters were restored to control group levels in the AFB1+Se group.These results suggested that sodium selenite supplied in the diet,could effectively inhibit AFB1-induced apoptosis and cell cycle blockage in renal cells of broiler.
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