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Polysaccharides are the most abundant optically active polymers on the earth and can be easily modified to carbamate group through the reaction with isocyanate group.The carbamate group-modified polysaccharide can be used the CSP for enantioseparation of chiral compounds.In this study, we firstly prepared the CSP based on cellulose with crown ether group by reaction of cellulose and 4-isocyanatebenzo-15-crown-5, which is prepared by reaction of 4-aminobenzo-15-crown-5 and phosgene.The obtained CSP with crown ether group was characterized by FT-IR, 13C-NMR and element analysis.In order to compare enantioseparation efficiency of the CSP with crown ether group and that of commercial CHIRALCEL OD with phenyl group, cellulose tris(3,5-dimethylphenyl carbamate) was also prepared according to Okamoto method.The enantioseparation of chiral compounds including chiral drugs and amino acid is in progress.