【摘 要】
：
There were several strategies enhancing permeation of gancyclovir (GCV) into the retinal and corneal tissues.These approaches could lead to significant impr
【出 处】
：
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
There were several strategies enhancing permeation of gancyclovir (GCV) into the retinal and corneal tissues.These approaches could lead to significant improvement in therapeutic options and efficacy,which in turn might lead to reduced frequency of drug administration and/or surgery.In previous studies,a series of both mono-and di-acyl ester GCV prodrugs were evaluated in an attempt to improve the ocular bioavailability and efficacy of this antiviral agent.Although the lipophilic acyl ester prodrug of GCV had equivalent GCV in vitro antiviral activity,the enhanced lipophilicity and poor aqueous solubility constrained their use as topical,intravitreal or systemic agents.
其他文献
社会主义人道主义,应当是社会主义精神文明建设及道德建设的一个基本内容。按照马克思主义基本原理,人道主义乃是被把握在价值观念层次的商品流通或市场机制,因之,社会主义
伴随着现代教学理念的不断发展,小学阶段越来越重视体育课程。而在小学体育课程当中,篮球的教学又是重中之重。但是在进行篮球教学的时候,有些学生由于对篮球缺乏兴趣,因此不
Thiazolidin-4-one derivatives had been paid extensive attention by virtue of their good anti-diabetic,anti-tumor and anti-viral activities [1].Recently,thia
香港电讯作为一家总资产仅次于汇丰控股，市值超过2200亿港元的英资大公司。长期以来，它的高级行政管理人员一直是由英国人出任，华人在公司里只能担当一些不重要的辅助性工作。三
塑料小拱棚栽培是春甘蓝生产上一种简单易行的保护地栽培方式。具有增温、防冻、保墒、防风、护苗早发等作用,而且投资少,收益大。可在一季或一年中多茬重复使用。近几年的
Hepatocellular carcinoma(HCC) is an aggressive and life-threatening disease which caused enormous number of deaths worldwide in 2008.Limited success of curr
在过去两期篇幅内,我们简单地介绍了产品研制过程,以及对产品(尤其指软件产品)价值之必要考虑条件(架构、连续性、覆盖).今期我们将从另一角度,具体地探讨一下软件开发的理想
经过半个世纪广大果树科技人员和果农的辛勤工作,锦橙不仅已成为四川甜橙的主栽优良品种,而且已是我国甜橙发展很快的良种之一,遍及湖北、湖南、贵州、福建、江西、浙江、广
Mycoepoxydiene(MED) is a cytotoxic polyketide that is isolated from the marine fungal strain Diaporthe sp.HLY-11,2,which is associated with mangroves;howeve
β-glucuronidase is an attractive reporter and prodrug-converting enzyme.The development of near-IR(NIR) probes for imaging of β-glucuronidase activity wou