Cancer microenvironment influences tumor cell behavior and therapy at primary and secondary growth sites.Because of its role in all the stages of cancer, it represents an attractive target for biomarker and drug discovery purposes.However, the precise nature of the molecules and cells that comprise cancer microenvironment, and how they influence the progression, dissemination and metastatic growth of cancer cells is poorly understood.The liver is a major metastasis-susceptible site and majority of patients with hepatic metastasis die from the disease in the absence of efficient treatments.Both micro architectural and functional factors work together to trap and kill circulating cancer cells, but also to make this territory one of the most common sites for cancer metastasis.