Metabolomics shows great promise for studying health and disease.However, still one may wish to have better tools available for biomarker discovery and to zoom into mechanisms.In this presentation several recent technological innovations will be discussed.New platforms such as CE-MS have been recently added to our set of routine methods.Improvements in often applied lipid profiling have been achieved.One important recent improvement was the structure elucidation of lipids to reveal the position of fatty acids and double bonds.Next, miniaturization of analytical platforms offer new possibilities and the use of microfluidics for the analysis of small sample volumes will be discussed.Examples of biomarker discovery will be discussed, and strategies and examples how to use tracers to zoom futher into biological mechanisms.