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本文对阿斯匹林缓释片在不同的pH值缓冲液中的释放特性进行了研究,结果表明:本品在pH值为2.0-6.0的酸性条件下释放较慢,释放速度随pH值的增高逐渐增大;在pH大于7.0的偏碱性条件下释放较快,释放速度随pH值的增高明显加快。
The release characteristics of aspirin sustained-release tablets in different pH buffers were studied in this paper. The results showed that the release of aspirin tablets was slower under the acidic conditions of pH 2.0-6.0. The release rate varied with the pH value Increasing gradually increased; pH greater than 7.0 under alkaline conditions release faster, the release rate increased significantly with the pH value increased significantly.