Aim: To observe differences between Herba Ephedrae and Fructus Schisandrae on the angiogenesis for treating rat idiopathic pulmonary fibrosis induced by bleomycin. Methods: The rats were modeled by bleomycin, which divided into six groups to drug administration, ephedra alone, schisandra alone , the combination of the two drugs, hydrocortisone alone for 28 days. 7d and 28d, the rats were killed respectively for Pathological morphology examination microvascular density examination, Angiogenesis-related cytokines examination. Results: Both the Ephedra group and the hydrocortisone group had statistically significant on restraining the alveolitis grades and pulmonary fibrosis (P<0. 05) . The number of the blood vessel of the Ephedra group is higher than the Schisandra group and combination therapy group. At 7d, the level of ET-1 of the model group was at a higher level , and had more significant difference with the normal group (P<0. 01) .The level of 6-Keto-PGF1α of the treatment group rised, and there was significant difference between Ephedra, and combination therapy group and the normal group (P <0. 05) . Conclusion: Ephedra has positive effect on restrain the increase of Lung Coefficient. Combination therapy group can significantly restrain the pulmonary artery injury and can also restrain the angiogenesis of the arteries by reducing the level of ET-1 and promoting the level of 6-Keto-PGF1α in blood. Both Ephedra and schisandra can restrain alveolitis and the development of pulmonary fibrosis.