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Introduction: PMMA bone cement have been effectively used to treat osteoporotic spine compression fracture during this decade but it has some potential disadvantages especially it is not bioactive.The ideal bone cement for vertebroplasty should be 1) bioactive 2).low setting temperature 3).easy injectable 4) stiffness close to bone 5) can immediate load bearing.Objectives: The Strontium containing hydroapatite(Sr-HA) cement have following advantages:1)bioactive(osseointegration)2) low setting temperature of 58 C 3)the bending strength and modulus are closer to human cancellous.This objective of this study is to evaluation the safety and clinical results of Sr HA cement and vesselplasty applying to osteoporotic spine compression fracture.Materials & Methods: 48 pts with diagnosis of painful osteoporotic spine compression fracture after two months conservative treatment were treated by vertebroplasty using Sr-HA cement.Subjective ODQ(Oswestry Disability Questionnaire), VAS, cement leakage, anterior body high restore, adjacent compression fracture were assessed over 12 months.Results: The new bone formation at the interface of Sr-HA cement & bone was found in 66.7%(32/48) cases by x ray.VAS scores reduce from 8.8 to 1.9.ODQ show 71.1 pre-operation and 18.9 post-operation.4.2% cases(2/48) have cement leakage but no clinical neurologic sign.Anterior body high show 34% restore.No complications of neurologic deficiency and infection was found.Only 4.1%(2/48) cases showed adjacent vertebra compression fracture.Conclusions: Sr-HA cement is a safety and efficient biomaterial in treating osteoporotic spine compression fracture.But a long term evaluation is still needed.