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Objective:To compare the regional differences in TCM syndromes of patients withcoronary heart disease (CHD) between North and South China. Methods:A total of 624patients with a diagnosis of CHD, confirmed by coronary angiography, were includedin the comparative analysis to identify the occurrence pattern, TCM syndromedistribution, and differences in syndrome combinations and deficiency or excesssyndrome types between North and South China. Results：The incidence of CHD tendedto be higher in North China compared with that in South China;the proportions ofpatients with a qi-deficiency syndrome, turbid phlegm syndrome, or blood stasissyndrome were generally higher in South China, while the proportion of patients witha cold congelation syndrome was identified to be higher in North China;comparedwith that in South China, the overall frequency of syndrome combinations tended tobe lower in North China;the most common types of TCM syndrome were excess syndromeand deficiency in root and excess in superficiality syndrome in North and South China,respectively. Conclusion:A regional difference exists in the TCM syndromes ofpatients with CHD between North and South China, indicating that the prevention andtreatment of CHD in South China should not only focus on promoting blood circulationand removing blood stasis, but also include supplementing qi and eliminating phlegm.