【摘 要】
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Abnormalities in calcium phosphate (Ca-P) metabolism and Ca-P related hormones are well documented in patients with essential hypertension (EH), but less in
【机 构】
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Department of Nephrology/Endo Hospital of the Ministry of Interior Affairs and Administration Depart
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Abnormalities in calcium phosphate (Ca-P) metabolism and Ca-P related hormones are well documented in patients with essential hypertension (EH), but less in patients with non insulin dependent diabetes mellitus (NIDDM).Our study was designed to assess the responsiveness ofparathormone (PTH) secretion to an oral phosphate load in patients with EH-NTS and hypertensive patients with NIDDM-CNT.Both NTS and CNT patients are characterized by an abnormal calcium and phosphate metabolism and exaggerated response of PTH secretion to an oral phosphate load as compared with controls.Probably hypertension and not NIDDM seems to be the leading cause of calcium-phosphate abnormalities in hypertensive diabetic patients.We also analyzed the effects of antihypertensive treatment on responsiveness of PTH secretion to an oral phosphate load in NTS and CNT.From results obtained in our study inhibitors of converting enzyme but not calcium blockers seem to exert a suppressive effect on PTH secretion in both groups of patients.
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