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Introduction: The aim of this study was to evaluate mandibular asymmetry in different skeletal patterns with Cone-beam computed tomography(CBCT).Methods: A total of 110 subjects(65 females and 45 males)aged from 18 to 30 years were selected from patients who had undergone CBCT examinations retrospectively.All the subjects were divided into three groups according to the skeletal patterns: Class Ⅰ(Cl Ⅰ: 0≤ANB≤5),Class Ⅱ(Cl Ⅱ: ANB>5)and Class Ⅲ(Cl Ⅲ: ANB<0).In addition,each group was also divided into two subgroups according to gender.Condylar(Co-Sig),ramus(Go-Sig)and condyle-plus-ramus(Co-Go)asymmetry were assessed by identifying landmarks on the reconstructed images with a 3-dimentional(3D)reference plane.The coordinates of the landmarks were calculated statistically,so were the coordinates of point Menton(Me).