【摘 要】
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Most of the amino acids have an asymmetric carbon at the alpha position.Although the L-amino acids are abundantly present in higher animals, the minor compo
【机 构】
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Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 8
【出 处】
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第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
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Most of the amino acids have an asymmetric carbon at the alpha position.Although the L-amino acids are abundantly present in higher animals, the minor component, D-amino acids are currently gradually recognized as the candidates of physiologically active substances and biomarkers.In mammals including human beings, several D-amino acids, such as D-Ser, D-Asp, D-Ala, D-Leu and D-Pro, were found and a sensitive and selective analytical method for the simultaneous determination of all proteinogenic amino acid enantiomers is highly required.To accomplish this aim, we have established an enantioselective micro-2D-HPLC system for all proteinogenic amino acids.Amino acids were derivatized with a highly sensitive fluorescent reagent, 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F), and the derivatives were determined using a micro-2D-HPLC system combining a microbore-reversed-phase column (1st dimension) and a set of narrowbore-enantioselective columns (2nd dimension).
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