Autophagy is an important innate safeguard mechanism for protecting an organism against invasion by unwanted pathogens.We previously discovered that KSHV vBcl2 and vFLIP interact with Beclin-1 and Atg3 respectively to block autophagy signaling.Here, we report that the vBcl2 and vFLIP inhibit cGAS-mediated autophagy during de novo infection in the context of virus.