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Objective: To assess the different reconstruction methods in PET (positron emission tomography)image, especially the brand or patent.Comparing their advantages and weakness, aim at providing a reliable basis to the clinical application.Method: Subjects: Twenty patients who suffered from cancer and PET phantom filled with different dosage 18F-FDG solution were participated in the study.All patients had primary lesions and other metastasis.Machine: Siemens Biograph-64 PET.CT (syngo MI.PET/CT 2009A).Reconstruction methods: TrueX and Iterative.Other reconstruction parameters such as iterative time, subsets, matrix and post filter were same.Selected positive patients and phantom make qualitative and quantitative comparison.Data analysis: Told two people count the lesions of every patient using the different reconstruction methods.Pay more attention on the edged lesions.Then we can know the lesion detection rate.This was the qualitative comparison.For the phantom, the background is filled with 6000Bq/ml 18F-FDG water solution.The hot area filled with 30000Bq/ml 18F-FDG water solution.Same slice was extracted from reconstructed image for doing following analysis: the ratio(R) between hot area and cold area, the standard deviation (SD)on background and hot area.This was the quantitative comparison.Results: From the qualitative comparison, lesion detection rate is different.This TrueX can find 205 lesions, but the other method can find 203 lesions.There are significant differences of SD and ratio between TrueX and Iterative according to the phantom experiment.SD in Iterative is twice as TureX, especially in edged area.The difference is more evidence.The ratio between hot area and cold area is also different.TureX is higher than Iterative.This can prove TrueX has the better image quality.Conclusion: TrueX can improve the lesion detection rate, provide 2x signal to noise improvement and uniform spatial resolution throughout the entire FOV.It can improve the clinical diagnosis level.So, in daily work, we recommend using TrueX reconstruction method.