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Introduction Hemophagocytic lymphohistiocytosis (HLH),also known as hemophagocytic syndrome (HPS) is characterized by cytokines storm and uncontrolled activation of macrophages.Secondary HLH in adults may occur in different occasions,including infections,autoimmune diseases,carcinomas and hematologic malignancies,in which lymphoma-associated hemophagocytic lymphohistiocytosis(LA-HLH) has a high fatality rate and the worst outcome.