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In Parkinsons disease (PD) , dopamin ergic neuron damage/death causes the release of soluble substances that are selectively toxic to neighboring/ad ditional dopaminergic neurons through the activation of microglia.Heat shock protein 60 (Hsp60) can be re leased from injured cells of central nervous system (CNS) to activate microglia.However, its expression and role in PD has not been well understood.Here, we demonstrated the time-course expression of Hsp60,which decreased gradually and then rose back in an in vivo model of PD.