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In a series of experiments involving samples of healthy and substance-dependent populations, we investigated the neural and cognitive overlap among different types of self-control.In Experiment 1, we obtained high-resolution structural MRI brain scans of abstinent methamphetamine-dependent and healthy control participants who also completed tests of motor and affective self-control (stop signal and cognitive reappraisal tasks, respectively).In the healthy individuals, motor and affective self-control measures were correlated with one another and with gray matter intensity in ventrolateral prefrontal cortex (VLPFC).