新糖脂类化合物以细胞壁靶点的抗菌作用机制研究

来源 :第十三次全国临床药理学学术大会 | 被引量 : 0次 | 上传用户：huolong820

【摘要】

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【作者】

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钱霞齐慧敏张再红王鹏李英霞

【机构】

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北京大学第一医院临床药理研究所北京 100034 中国海洋大学药学院,山东青岛 266003

【出处】

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第十三次全国临床药理学学术大会

【发表日期】

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2012年10期

【关键词】

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糖脂类化合物抗菌机制金黄色葡萄球菌细胞壁

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　　目的：研究新化合物二鼠李糖脂衍生化合物7(dirhamnoside derivative compound7 DDC7)和鼠李糖脂cleistrioside-5(C5)抗革兰阳性球菌的作用机制.方法：分离纯化金黄色葡萄球菌ATCC29213细胞壁.依据新化合物对ATCC29213已知MIC结果,用肉汤二倍稀释法,检测新化合物加入不同浓度细胞壁后对ATCC29213的MIC.结果：新化合物对ATCC29213的MIC为16ug/ml.当加入细胞壁浓度≥32ug/ml,可以阻断新化合物对ATCC29213的抑菌作用.结论：糖脂新类化合物抗菌作用部位在革兰阳性球菌细胞壁细胞壁上.

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新糖脂类化合物以细胞壁靶点的抗菌作用机制研究

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