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目的:探讨老年人超敏C反应蛋白、尿微量蛋白与心脑血管疾病发生、发展关系。方法:对196例70岁以上老年人通过血压和心电图结果分为三组,其中高血压62例;冠心病45例;对照组89例,空腹采血,留取晨尿,分别用BN-Prospec特种蛋白分析仪,测定尿微量白蛋白(ABLU)及超敏C反应蛋白(HS-CRP),用OLYMPUS2700全自动生化分析仪测定空腹血糖(GLU)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDLC)。结果:高血压组、冠心病组HS-CRP、ABLU结果均明显增高;与正常对照组有非常显著性差异(P<0.05)。且HS-CRP、ABLU与冠心病其他危险因素GLU、TC正相关,HS-CRP与ABLU高度正相关。结论:对老年人进行HS-CRP与ABLU定期检查利于监测动脉粥样硬化形成的过程,以便早期发现相关危险因素并进行干预,更有效的降低由心脑血管疾病引起的病残率和病死率。
Objective: To investigate the relationship between the occurrence and development of hypersensitive C-reactive protein and urinary microalbumin in the elderly and cardiovascular and cerebrovascular diseases. Methods: The results of blood pressure and electrocardiogram were divided into three groups according to the results of blood pressure and electrocardiogram in 196 elderly patients over 70 years old, including 62 cases of hypertension, 45 cases of coronary heart disease, 89 cases of control group, fasting blood and morning urine, Protein analyzer was used to measure the levels of fasting blood glucose (GLU), total cholesterol (TC), triglyceride (TG) and urinary microalbuminuria (ABLU) and high sensitivity C-reactive protein (HS-CRP) by OLYMPUS2700 automatic biochemical analyzer. , High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDLC). Results: The results of HS-CRP and ABLU in hypertensive group and coronary heart disease group were significantly higher than those in normal control group (P <0.05). And HS-CRP, ABLU and other risk factors of coronary heart disease GLU, TC positive correlation, HS-CRP and ABLU highly correlated. Conclusion: The routine examination of HS-CRP and ABLU in the elderly is helpful to monitor the process of atherosclerosis in order to detect and intervene the relevant risk factors in the early stage and reduce the morbidity and mortality of cardiovascular and cerebrovascular diseases .